Stabilised pathway and its anti-oxygen/glucose deprived activity about ligustilide, as a pharmacodynamic marker for Angelica sinensis (Oliv) Diles or Ligusticum chuanxiong Hort

The inherent structural instability and very low bioavailability of ligustilide (Lig) lead to the limited application of the clinical neuroprotection. We developed a stabilised method for Lig, which involved a chemical synthesis between cyclopropylamine and the active phthalides extract included Lig from