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Extracellular Vesicular miRNA in Pancreatic Cancer: From Lab to Therapy

胰腺癌 转移 小RNA 癌症 癌症研究 血管生成 医学 放射治疗 癌细胞 微泡 生物信息学 免疫学 生物 内科学 生物化学 基因
作者
Prashant Tiwari,Poojhaa Shanmugam,Vamika Karn,Saurabh Gupta,Richa Mishra,Sarvesh Rustagi,Mandeep Chouhan,Devvret Verma,Niraj Kumar Jha,Sanjay Kumar
出处
期刊:Cancers [MDPI AG]
卷期号:16 (12): 2179-2179 被引量:2
标识
DOI:10.3390/cancers16122179
摘要

Pancreatic cancer is a prevalent lethal gastrointestinal cancer that generally does not show any symptoms until it reaches advanced stages, resulting in a high mortality rate. People at high risk, such as those with a family history or chronic pancreatitis, do not have a universally accepted screening protocol. Chemotherapy and radiotherapy demonstrate limited effectiveness in the management of pancreatic cancer, emphasizing the urgent need for innovative therapeutic strategies. Recent studies indicated that the complex interaction among pancreatic cancer cells within the dynamic microenvironment, comprising the extracellular matrix, cancer-associated cells, and diverse immune cells, intricately regulates the biological characteristics of the disease. Additionally, mounting evidence suggests that EVs play a crucial role as mediators in intercellular communication by the transportation of different biomolecules, such as miRNA, proteins, DNA, mRNA, and lipids, between heterogeneous cell subpopulations. This communication mediated by EVs significantly impacts multiple aspects of pancreatic cancer pathogenesis, including proliferation, angiogenesis, metastasis, and resistance to therapy. In this review, we delve into the pivotal role of EV-associated miRNAs in the progression, metastasis, and development of drug resistance in pancreatic cancer as well as their therapeutic potential as biomarkers and drug-delivery mechanisms for the management of pancreatic cancer.
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