克拉斯
癌症研究
GTP酶
化学
药理学
计算生物学
突变
生物
生物化学
基因
作者
Yuhang Li,Le Yang,Xiaoran Li,Xiaojin Zhang
标识
DOI:10.1080/13543776.2024.2369630
摘要
Introduction KRAS is a critical oncogenic protein intricately involved in tumor progression, and the difficulty in targeting KRAS has led it to be classified as an 'undruggable target.' Among the various KRAS mutations, KRASG12D is highly prevalent and represents a promising therapeutic target, yet there are currently no approved inhibitors for it.
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