赫拉
植物化学
细胞毒性T细胞
化学
立体化学
传统医学
癌细胞系
糖
生物
癌细胞
有机化学
体外
生物化学
癌症
医学
遗传学
作者
Juan Long,Jia-Cheng Ouyang,Yu‐Hao Luo,Qi-Jing Wu,Xiao-Tong Liao,Zhi-Le Chen,Qilin Wang,Xiao-Yan Liang,Li Liu,Xue-Mei Yang,Xiao‐San Li
标识
DOI:10.1080/14786419.2022.2113876
摘要
Phytochemical investigations on the fruits of Cascabela thevetia (L.) Lippold led to obtain three new cardenolides (1-3) and five known analogues (4-7). Their structures were elucidated by means of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopic data analysis. Compounds 1 and 2 represent the first examples of naturally occurring cardenolides with 19-nor-5(10)-ene group and α-l-3-demethyl-thevetose, respectively. Compound 3 is a rare C-nor-D-homocardenolide in nature. All isolated cardenolides (1-7) were evaluated for their cytotoxic activities against four human cancer cell lines (MCF-7, HCT-116, HeLa and HepG2), and the results indicated the compounds with sugar units (1, 2, 4, and 5) exhibited stronger cytotoxic activities with IC50 values ranging between 0.022 and 0.308 μM.
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