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Surface Modification of Poly(Vinylchloride) for Manufacturing Advanced Catheters

表面改性 材料科学 生物相容性 润湿 聚合物 纳米技术 药物输送 接触角 生物材料 化学改性 生物医学工程 化学工程 复合材料 高分子化学 冶金 工程类 医学
作者
Oana Cristina Duta,Aurel Mihail Țîțu,Alexandru Marin,Anton Ficai,Denisa Ficai,Ecaterina Andronescu
出处
期刊:Current Medicinal Chemistry [Bentham Science]
卷期号:27 (10): 1616-1633 被引量:14
标识
DOI:10.2174/0929867327666200227152150
摘要

Polymeric materials, due to their excellent physicochemical properties and versatility found applicability in multiples areas, including biomaterials used in tissue regeneration, prosthetics (hip, artificial valves), medical devices, controlled drug delivery systems, etc. Medical devices and their applications are very important in modern medicine and the need to develop new materials with improved properties or to improve the existent materials is increasing every day. Numerous reasearches are activated in this domain in order to obtain materials/surfaces that does not have drawbacks such as structural failure, calcifications, infections or thrombosis. One of the most used material is poly(vinylchloride) (PVC) due to its unique properties, availability and low cost. The most common method used for obtaining tubular devices that meet the requirements of medical use is the surface modification of polymers without changing their physical and mechanical properties, in bulk. PVC is a hydrophobic polymer and therefore many research studies were conducted in order to increase the hydrophilicity of the surface by chemical modification in order to improve biocompatibility, to enhance wettability, reduce friction or to make lubricious or antimicrobial coatings. Surface modification of PVC can be achieved by several strategies, in only one step or, in some cases, in two or more steps by applying several techniques consecutively to obtain the desired modification / performances. The most common processes used for modifying the surface of PVC devices are: plasma treatment, corona discharge, chemical grafting, electric discharge, vapour deposition of metals, flame treatment, direct chemical modification (oxidation, hydrolysis, etc.) or even some physical modification of the roughness of the surface.
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