乙醇胺
前药
药品
中枢神经系统
药理学
血脑屏障
神经科学
化学
生物
生物化学
作者
Asfree Gwanyanya,Christie Nicole Godsmark,Roisin Kelly‐Laubscher
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2020-12-15
卷期号:21 (2): 108-117
被引量:10
标识
DOI:10.2174/1871527319999201211204645
摘要
Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process, ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological actions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer's disease. This mini-review focuses on the effects of ethanolamine on the CNS and highlights the possible implications of these effects for drug design.
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