Low Prevalence of Helicobacter pylori Infection in IBD Patients from a Predominantly African/Caribbean Urban Center

医学 内科学 人口 幽门螺杆菌 溃疡性结肠炎 胃肠病学 过度拥挤 炎症性肠病 疾病 免疫学 环境卫生 经济 经济增长
作者
Ali M. Ahmed,Charles Kozcka,Ryan J. Nelson,Umair Masood,Amit Alam,Garrett Lawlor
出处
期刊:The American Journal of Gastroenterology [Lippincott Williams & Wilkins]
卷期号:108: S515-S515 被引量:1
标识
DOI:10.14309/00000434-201310001-01709
摘要

Purpose:Helicobacter pylori (HP) is a gram negative bacterium which can survive the harsh acidic environment of the human stomach, infecting 50% of people. In developing countries, this value can be up to 90%. HP infection is associated with the development of peptic ulcer disease, gastric cancer, and MALT lymphoma. Risk factors include lower socioeconomic status, overcrowding, poor hygiene, and living in a developing country. Published rates of HP infection in the Caribbean ranges from 55%-70%. HP detection can include histologic testing of the endoscopic biopsy specimens or fecal antigen. The latter is often also used to document HP eradication after therapy or to monitor progression in the presence of continued symptoms. Patients with inflammatory bowel disease (IBD) have lower HP infection rates than the rest of the population. In fact, some studies believe HP infection may be protective in the yet to be determined factors that are causative of IBD. A recent study demonstrated that the presence of HP was inversely associated with IBD, ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis. A recent meta-analysis reported IBD populations having a HP prevalence of 27.1% and control populations with 40.9%. However, this impact in underserved urban areas, is not well-described. The aim of our study was to determine the prevalence of HP in an urban population of Afro-Caribbean patients with IBD. Methods: IBD patients (N=347) were identified by ICD-9 coding and were retrospectively evaluated for the presence of HP by positive histology. A control group was determined by a database of patients with abdominal symptoms (N=321). Both groups were compared for HP status and demographic data. The IBD group was evaluated on the basis of UC and CD. Results: The IBD cohort comprised a group with an average age 45 years, 86% black, 62% UC, 31% CD, and 7% indeterminate colitis. The control group was an older cohort at 59 years, and 67% black. The IBD group was found to have an HP prevalence of 3.4%, as compared to 10.3% in our control group. Both these values are significantly lower than those reported in the literature, but consistent with the finding of lower HP rates in IBD patients. The control group was evaluated from a database of N=321 patients seen from 2009-2012. The average age was 59 years. 67% were black, 24% Afro-Caribbean. HP status was determined using biopsy or by HP stool antigen as a surrogate. Conclusion: These findings report a lower HP prevalence in both groups in this urban Afro-Caribbean population, as compared to those expected to be found in a U.S. cohort or either IBD (3.4%) or non-IBD (10.3%) populations. However, the lower HP prevalence, as compared to the control group, is consistent with recent literature.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
淡淡的小蘑菇完成签到 ,获得积分10
1秒前
G_Serron完成签到,获得积分10
2秒前
swordshine完成签到,获得积分10
2秒前
Anonymous完成签到,获得积分10
6秒前
medzhou完成签到,获得积分10
10秒前
儒雅的千秋完成签到,获得积分10
18秒前
普鲁卡因发布了新的文献求助10
21秒前
小雯完成签到,获得积分10
22秒前
搞怪梦寒完成签到,获得积分20
23秒前
喵了个咪完成签到 ,获得积分10
24秒前
mc完成签到 ,获得积分10
26秒前
量子星尘发布了新的文献求助10
29秒前
30秒前
30秒前
虚幻谷波完成签到,获得积分10
32秒前
ruochenzu发布了新的文献求助10
35秒前
小马甲应助搞怪梦寒采纳,获得10
37秒前
firewood完成签到 ,获得积分10
38秒前
天天快乐应助普鲁卡因采纳,获得10
40秒前
orixero应助NXK采纳,获得10
40秒前
bjr完成签到 ,获得积分10
42秒前
研友_LwlAgn完成签到,获得积分10
46秒前
陈昊完成签到,获得积分10
54秒前
55秒前
tian发布了新的文献求助10
57秒前
1分钟前
1分钟前
龙舞星完成签到,获得积分10
1分钟前
1分钟前
王涉发布了新的文献求助10
1分钟前
普鲁卡因发布了新的文献求助10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
柚子完成签到,获得积分10
1分钟前
1分钟前
马儿饿了要吃草完成签到,获得积分10
1分钟前
1分钟前
sudor123456完成签到,获得积分10
1分钟前
NXK发布了新的文献求助10
1分钟前
打打应助普鲁卡因采纳,获得10
1分钟前
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022