Low Prevalence of Helicobacter pylori Infection in IBD Patients from a Predominantly African/Caribbean Urban Center

医学 内科学 人口 幽门螺杆菌 溃疡性结肠炎 胃肠病学 过度拥挤 炎症性肠病 疾病 免疫学 环境卫生 经济 经济增长
作者
Ali M. Ahmed,Charles Kozcka,Ryan J. Nelson,Umair Masood,Amit Alam,Garrett Lawlor
出处
期刊:The American Journal of Gastroenterology [Lippincott Williams & Wilkins]
卷期号:108: S515-S515 被引量:1
标识
DOI:10.14309/00000434-201310001-01709
摘要

Purpose:Helicobacter pylori (HP) is a gram negative bacterium which can survive the harsh acidic environment of the human stomach, infecting 50% of people. In developing countries, this value can be up to 90%. HP infection is associated with the development of peptic ulcer disease, gastric cancer, and MALT lymphoma. Risk factors include lower socioeconomic status, overcrowding, poor hygiene, and living in a developing country. Published rates of HP infection in the Caribbean ranges from 55%-70%. HP detection can include histologic testing of the endoscopic biopsy specimens or fecal antigen. The latter is often also used to document HP eradication after therapy or to monitor progression in the presence of continued symptoms. Patients with inflammatory bowel disease (IBD) have lower HP infection rates than the rest of the population. In fact, some studies believe HP infection may be protective in the yet to be determined factors that are causative of IBD. A recent study demonstrated that the presence of HP was inversely associated with IBD, ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis. A recent meta-analysis reported IBD populations having a HP prevalence of 27.1% and control populations with 40.9%. However, this impact in underserved urban areas, is not well-described. The aim of our study was to determine the prevalence of HP in an urban population of Afro-Caribbean patients with IBD. Methods: IBD patients (N=347) were identified by ICD-9 coding and were retrospectively evaluated for the presence of HP by positive histology. A control group was determined by a database of patients with abdominal symptoms (N=321). Both groups were compared for HP status and demographic data. The IBD group was evaluated on the basis of UC and CD. Results: The IBD cohort comprised a group with an average age 45 years, 86% black, 62% UC, 31% CD, and 7% indeterminate colitis. The control group was an older cohort at 59 years, and 67% black. The IBD group was found to have an HP prevalence of 3.4%, as compared to 10.3% in our control group. Both these values are significantly lower than those reported in the literature, but consistent with the finding of lower HP rates in IBD patients. The control group was evaluated from a database of N=321 patients seen from 2009-2012. The average age was 59 years. 67% were black, 24% Afro-Caribbean. HP status was determined using biopsy or by HP stool antigen as a surrogate. Conclusion: These findings report a lower HP prevalence in both groups in this urban Afro-Caribbean population, as compared to those expected to be found in a U.S. cohort or either IBD (3.4%) or non-IBD (10.3%) populations. However, the lower HP prevalence, as compared to the control group, is consistent with recent literature.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
赵田完成签到 ,获得积分10
3秒前
3秒前
ira完成签到,获得积分10
6秒前
FashionBoy应助王忠凯采纳,获得10
8秒前
韭菜盒子发布了新的文献求助10
9秒前
wxx完成签到,获得积分10
10秒前
10秒前
英俊的铭应助222采纳,获得10
10秒前
看文献完成签到,获得积分0
10秒前
10秒前
激情的依凝完成签到,获得积分20
12秒前
坦率的从丹完成签到 ,获得积分10
14秒前
14秒前
bkagyin应助韭菜盒子采纳,获得10
14秒前
weijie完成签到,获得积分10
15秒前
sherwing2009发布了新的文献求助10
16秒前
zm发布了新的文献求助10
16秒前
djbj2022发布了新的文献求助10
18秒前
18秒前
19秒前
流星雨完成签到 ,获得积分10
22秒前
222发布了新的文献求助10
24秒前
26秒前
zhang完成签到 ,获得积分10
27秒前
zokor完成签到 ,获得积分0
27秒前
斯文败类应助激情的依凝采纳,获得10
28秒前
思源应助静默向上采纳,获得10
29秒前
英吉利25发布了新的文献求助20
30秒前
31秒前
Skywalk满天星完成签到,获得积分10
31秒前
Tin发布了新的文献求助10
31秒前
32秒前
32秒前
kelly完成签到,获得积分10
33秒前
smile完成签到,获得积分10
35秒前
韭菜盒子发布了新的文献求助10
37秒前
39秒前
刘刘完成签到,获得积分10
39秒前
等待的幼晴完成签到,获得积分10
39秒前
水本无忧87完成签到,获得积分10
39秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513393
关于积分的说明 11167478
捐赠科研通 3248836
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875131
科研通“疑难数据库(出版商)”最低求助积分说明 804664