The Impact of Statin Drug Use on All-Cause Mortality in Patients With COPD

医学 慢性阻塞性肺病 他汀类 内科学 危险系数 队列 比例危险模型 人口 队列研究 药方 药品 死因 置信区间 疾病 药理学 环境卫生
作者
Adam Raymakers,Mohsen Sadatsafavi,Don D. Sin,Mary A. De Vera,Larry D. Lynd
出处
期刊:Chest [Elsevier BV]
卷期号:152 (3): 486-493 被引量:47
标识
DOI:10.1016/j.chest.2017.02.002
摘要

Background

Patients with COPD are often prescribed statin drugs due to the increased prevalence of cardiovascular disease. There is considerable debate about the benefits conferred by statin drugs in patients with COPD. This study evaluates the association of statin drug use with all-cause and lung-related mortality in patients with COPD.

Methods

This study uses population-based administrative data for the province of British Columbia, Canada. A cohort of patients with COPD was identified based on individual patient prescription records. Statin drug exposure was ascertained in the 1-year period after the COPD diagnosis. The primary and secondary outcomes, all-cause and lung-related mortality, respectively, were evaluated in the 1-year period thereafter using multivariate Cox proportional hazards models and several definitions of medication exposure.

Results

There were 39,678 patients with COPD that met the study inclusion criteria. Of them, 7,775 (19.6%) had received at least one statin drug dispensed in the exposure ascertainment window. There were 1,446 all-cause deaths recorded in the cohort in the 1-year period after exposure ascertainment. In multivariate analysis, the estimated hazard ratio (HR) for statin drug exposure was 0.79 (95% CI, 0.68-0.92; P = .0016), suggesting a 21% reduction in the risk from statin drug use on all-cause mortality. For lung-related mortality, there was also a considerable reduction in the risk for all-cause mortality from statin drug use (HR, 0.55; 95% CI, 0.32-0.93; P = .0254). These results were robust to different specifications of the exposure ascertainment window.

Conclusions

This study shows that statin drug use in a population-based cohort of patients with COPD may confer benefits regarding reduced lung-related and all-cause mortality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
1秒前
wuy发布了新的文献求助10
3秒前
3秒前
4秒前
sanyecai发布了新的文献求助10
5秒前
5秒前
7秒前
7秒前
Volcano发布了新的文献求助10
8秒前
9秒前
星辰大海应助拓小八采纳,获得10
10秒前
Tao发布了新的文献求助10
11秒前
11秒前
Tangviva1988发布了新的文献求助10
11秒前
阳光沛柔发布了新的文献求助10
12秒前
SYLH应助cyn0762采纳,获得30
13秒前
17秒前
打打应助Tine采纳,获得30
18秒前
研友_VZG7GZ应助EED采纳,获得10
19秒前
缥缈问柳应助wjw采纳,获得10
19秒前
DijiaXu应助朝朝采纳,获得10
21秒前
sanyecai完成签到,获得积分10
21秒前
李健的小迷弟应助高铭泽采纳,获得10
24秒前
Zsl121完成签到,获得积分10
25秒前
25秒前
爆米花应助肖肖采纳,获得10
26秒前
26秒前
冬至完成签到,获得积分10
27秒前
28秒前
shenzhou9完成签到,获得积分10
28秒前
量子星尘发布了新的文献求助10
28秒前
29秒前
lll完成签到,获得积分20
31秒前
欣喜豌豆完成签到,获得积分10
33秒前
彭于晏应助雨过天晴采纳,获得10
33秒前
李健的小迷弟应助唐_采纳,获得10
34秒前
云辞忧发布了新的文献求助10
34秒前
华仔应助Livrik采纳,获得10
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035