Studies on fatty acid ω-oxidation antiketogenic effect and gluconeogenicity of dicarboxylic acids

1. Administration of dicarboxylic acids to starving rats decreased the concentration of ketone bodies in the blood. 2. Incorporation of 14C into blood glucose was greater from dicarboxylic acids than from monocarboxylic acids. 3. These results suggest that ω-oxidation may be important for production of succinyl-CoA from fatty acids. 4. In starving or diabetic rats about 15% of palmitic acid were subjected to ω-oxidation and then β-oxidation.