发光体
电化学发光
生物传感器
纳米技术
生物相容性
金属有机骨架
化学
材料科学
发光
电极
吸附
光电子学
有机化学
物理化学
冶金
作者
Jiaojiao Zhou,Yun Li,Wenjing Wang,Xuecai Tan,Zhicheng Lü,Heyou Han
标识
DOI:10.1016/j.bios.2020.112332
摘要
Metal-organic frameworks (MOFs) as porous materials have attracted much attention in various fields such as gas storage, catalysis, separation, and nanomedical engineering. However, their applications in electrochemiluminescence (ECL) biosensing are limited due to the poor conductivity, lack of modification sites, low stability and specificity, and weak biocompatibility. Integrating the functional materials into MOF structures endows MOF composites with improved conductivity and stability and facilitates the design of ECL sensors with multifunctional MOFs, which are potentially advantageous over their individual components. This review summarizes the strategies for designing ECL-active MOF composites including using luminophore as a ligand, in situ encapsulation of luminophore within the framework, and post-synthetic modification. As-prepared MOF composites can serve as innovative emitters, luminophore carriers, electrode modification materials and co-reaction accelerators in ECL biosensors. The sensing applications of ECl-active MOF composites in the past five years are highlighted including immunoassays, genosensors, and small molecule detection. Finally, the prospects and challenges associated with MOF composites and their related materials for ECL biosensing are tentatively proposed.
科研通智能强力驱动
Strongly Powered by AbleSci AI