Rivastigmine in Parkinson's Disease Dementia with Orthostatic Hypotension

竞争对手 直立生命体征 痴呆 安慰剂 医学 帕金森病 血压 麻醉 疾病 内科学 多奈哌齐 病理 替代医学
作者
Alberto J. Espay,Luca Marsili,Abhimanyu Mahajan,Andrea Sturchio,Rashidkhan Pathan,Andrea Pilotto,Damodaran Solai Elango,Nicole Pezous,Mario Masellis,Baltazar Gomez‐Mancilla
出处
期刊:Annals of Neurology [Wiley]
卷期号:89 (1): 91-98 被引量:18
标识
DOI:10.1002/ana.25923
摘要

Objective The purpose of this study was to evaluate if the cognitive benefit of rivastigmine is affected by the presence of orthostatic hypotension (OH) in patients with Parkinson's disease dementia (PDD). Methods We conducted a post hoc analysis on 1,047 patients with PDD from 2 randomized controlled trials comparing rivastigmine versus placebo at week 24 (n = 501) and rivastigmine patch versus capsule at week 76 (n = 546). A drop ≥ 20 mm Hg in systolic blood pressure (SBP) or ≥ 10 in diastolic blood pressure (DBP) upon standing classified subjects as OH positive (OH+); otherwise, OH negative (OH‐). The primary end point was the Alzheimer's Disease Assessment Scale ‐ Cognitive subscale (ADAS‐Cog) at week 24 and the Mattis Dementia Rating Scale (MDRS) at week 76, using intention‐to‐treat with retrieved dropout at week 24 and observed cases at week 76, consistent with the original analyses. Results Overall safety was comparable between OH+ (n = 288, 27.5%) and OH‐ (n = 730, 69.7%), except for higher frequency of syncope (9.2%) in the OH+ placebo arm. The placebo‐adjusted effect of rivastigmine on ADAS‐Cog at week 24 was 5.6 ± 1.2 for OH+ and 1.9 ± 0.9 in OH‐ ( p = 0.0165). Among subjects with OH, the MDRS change from baseline at week 76 was higher for rivastigmine capsules versus patch (10.6 ± 2.9 vs ‐1.5 ± 3.0, p = 0.031). The overall prevalence of OH was lower for rivastigmine than placebo at week 24 (28.3% vs 44.6%, p = 0.0476). Interpretation The cognitive benefit from rivastigmine is larger in patients with PDD with OH, possibly mediated by a direct antihypotensive effect. ANN NEUROL 2021;89:91–98
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zhanghw发布了新的文献求助10
刚刚
3秒前
ElbingX发布了新的文献求助40
3秒前
3秒前
3秒前
佳佳应助科研韭菜采纳,获得10
4秒前
顾矜应助王染墨采纳,获得10
4秒前
dong应助lucy采纳,获得10
5秒前
6秒前
酷波er应助明芬采纳,获得30
6秒前
治治治发布了新的文献求助10
6秒前
6秒前
今天洗头了嚒关注了科研通微信公众号
6秒前
烟花应助阿冰采纳,获得10
6秒前
科研鸟发布了新的文献求助10
6秒前
孙佳婷完成签到 ,获得积分10
7秒前
Ava应助科yt采纳,获得10
8秒前
深情安青应助梨里采纳,获得10
9秒前
9秒前
斯文败类应助禾晏采纳,获得10
9秒前
9秒前
9秒前
Tolerate发布了新的文献求助10
10秒前
10秒前
10秒前
ycccccc完成签到 ,获得积分10
11秒前
12秒前
12秒前
熊金艳给熊金艳的求助进行了留言
12秒前
上官若男应助蔡6705采纳,获得10
13秒前
ke发布了新的文献求助10
13秒前
NexusExplorer应助cym采纳,获得10
14秒前
宁祚完成签到,获得积分10
14秒前
零零发布了新的文献求助30
15秒前
15秒前
dylaner发布了新的文献求助10
15秒前
ding应助假发君采纳,获得10
16秒前
玛卡巴卡发布了新的文献求助10
16秒前
xiaose发布了新的文献求助10
17秒前
19秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976177
求助须知:如何正确求助?哪些是违规求助? 3520366
关于积分的说明 11202970
捐赠科研通 3256899
什么是DOI,文献DOI怎么找? 1798535
邀请新用户注册赠送积分活动 877725
科研通“疑难数据库(出版商)”最低求助积分说明 806516