[Role of cytokines in sepsis and its current situation of clinical application].

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, which is a global health crisis. The cytokines are a class of protein mediators secreted by cells with low molecular weights and biological activity. There are two types of cytokines, pro-inflammatory and anti-inflammatory cytokines, participating in regulation of immunity and inflammation in sepsis. Cytokines are also used as biomarkers for early warning, diagnosis, and prognostic assessment of sepsis and as therapeutic targets for prevention and treatment of sepsis. This paper briefly summarizes the research advance of some cytokines in sepsis and the related work carried out by author's institute, and elaborates the roles of cytokines in sepsis and their clinical application value, helping to provide some ideas and reference for the future research of cytokines in sepsis.脓毒症的定义为机体对感染反应失调而导致危及生命的器官功能障碍，是全球性的健康危机。细胞因子是一类由细胞分泌的具有生物活性的小分子蛋白物质，主要分为促炎性细胞因子和抗炎性细胞因子两大类，参与脓毒症的免疫及炎症调节。此外，细胞因子亦作为生物标志物用于脓毒症的预警、诊断及预后评估及作为治疗靶点用于脓毒症的防治。本文就近年脓毒症相关的部分细胞因子研究进展及笔者单位开展的相关工作做一简要总结，阐述其在脓毒症中的作用及临床应用价值，为未来脓毒症相关细胞因子的研究提供一点思路和参考。.