Recent advancements in synthesis and drug delivery utilization of polysaccharides-based nanocomposites: The important role of nanoparticles and layered double hydroxides

Drug delivery systems are explained as methods to deliver a specific drug to desired organs, tissues, and cells for drug release to diseases treatment. Recently, considerable development has been interested in stimuli-responsive nano-systems, which respond to the essential pathological and physicochemical issues in diseased sites. During the last decades, researchers in the world presented, investigated, and implemented novel different nanomaterials with a focus on developing drug delivery. Polysaccharides including chitosan, alginate, hyaluronic acid, gums, and cellulose, as natural bio-materials, are suitable candidates for designing and formulations of these nano-systems because of the outstanding merits such as bio-compatibility, bio-degradability, non-toxicity, and gelling characteristics. On the other side, nanoparticles including metals (Au, Ag), metal oxides (Fe3O4, ZnO, CuO), or non-metal oxides (SiO2) and also, layered double hydroxides nanostructures have appealed significant consideration in the fields of biomedical therapeutics and cancer therapy owing to the bio-compatibility, great surface area, good chemical and mechanical features, and also proper magnetic characteristics. This comprehensive review provides an overview of current advancements in drug delivery strategies, and manufacturing methods using chitosan, alginate, hyaluronic acid, gums, and also, metals, metal oxides, non-metal oxides, and LDHs for delivery system uses.