Preparation, characterization, and evaluation of tamarind seed polysaccharide-carboxymethylcellulose buccal films loaded with soybean peptides-chitosan nanoparticles

A novel buccal film based on tamarind seed polysaccharide (TSP) and carboxymethylcellulose (CMC) was developed for mucosal delivery of soybean peptides. Soybean peptides-chitosan nanoparticles (SP-CS) were prepared and incorporated into TSP-CMC film to improve the release behavior of soybean peptides in the oral cavity. The introduction of SP-CS enhanced the flexibility of TSP-CMC film and decreased its rigidity. The surfaces of composite films containing SP-CS were hydrophobic with water contact angles ranging from 101° to 114°. Structural characterization showed that the impregnation of SP-CS disrupted the hydrogen bonding between the film matrices, resulting in the loose internal structure of the films. For this reason, the composite films containing SP-CS exhibited good swelling ability and were easily eroded by saliva. Moreover, the results of release test showed that the initial burst release of soybean peptides was suppressed when the concentrations of SP-CS in the films exceeded 1%. The addition of low levels of SP-CS (1%–3%) increased the cumulative release of soybean peptides from the films compared to the film incorporating soybean peptides directly. This study suggested that the TSP-CMC films containing SP-CS displayed positive properties and could be promising candidates for the efficient delivery of soybean peptides.