接种疫苗
动作(物理)
疫苗佐剂
生物
病毒学
计算生物学
佐剂
医学
免疫学
计算机科学
物理
量子力学
作者
Nemat Shams,Amin Jaydari,Hamideh Najafi,Maryam Hataminejad,Sayyad Khanizadeh,Iman Pouladi
出处
期刊:Viral Immunology
[Mary Ann Liebert]
日期:2024-08-22
卷期号:37 (7): 324-336
标识
DOI:10.1089/vim.2024.0032
摘要
The widespread use of efficient vaccines against infectious diseases is regarded as one of the most significant advancements in public health and techniques for preventing and protecting against infectious diseases and cancer. Because the purpose of vaccination is to elicit an appropriate, powerful, and long-lasting immune response against the pathogen, compounds such as adjuvants must be used to enhance these responses. Adjuvants have been widely used since their discovery to boost immune responses, prevent diseases, and activate protective immunity. Today, several types of adjuvants with varying properties are available for specific applications. Adjuvants are supramolecular substances or complexes that strengthen and prolong the immune response to antigens. These compounds have long-term immunological effects and are low in toxicity. They also lower the amount of antigen or the number of immunogenic reactions needed to improve vaccine efficacy and are used in specific populations. This article provides an overview of the adjuvants commonly used in the vaccination industry, their respective mechanisms of action, and discusses how they function to stimulate the immune system. Understanding the mechanisms of action of adjuvants is crucial for the development of effective and safe vaccines.
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