脱盐
生物污染
材料科学
吸附
生物膜
涂层
乙二醇
PEG比率
蛋白质吸附
粘附
牙齿再矿化
齿面
牙科
纳米技术
搪瓷漆
化学
聚合物
有机化学
复合材料
膜
生物化学
经济
生物
细菌
医学
遗传学
财务
作者
Wenlin Chu,Haiqin Tang,Zhiyun Dong,Ailin Hou,Rongmin Qiu,Xinyuan Xu,Jiaojiao Yang,Libang He,Jun Luo,Jianshu Li
摘要
Dental caries is a biofilm-induced bacterial infectious oral disease, where the early attachment of proteins and pathogenic bacteria to tooth surfaces has been known as the main cause of biofilm formation. Typically, dental caries is commonly accompanied by mineral depletion of enamels, thus causing dental demineralization. Multifunctional materials are highly attractive candidates for treating dental caries. Herein, we successfully synthesized diblock copolymers poly(ethylene glycol)-b-poly(aspartic acid) (PEG-PAsp) and modified them with alendronate sodium (ALN) to serve as bioactive bifunctional coatings (PEG-PAsp-ALN) on teeth. The PEG segments are employed for inhibiting proteins and bacterial adhesion. In addition, due to the presence of both PAsp and ALN, a synergistically strong binding capacity could be achieved with the tooth surface, thus promoting rapid and thorough remineralization in situ, while maintaining excellent safety. The combination treatment can significantly suppress the biofilm formation, which is beneficial for alleviating the demineralization of enamels caused by bacteria, and further, facilitate remineralization in situ. This approach thus demonstrates the potential of the copolymer PEG-PAsp-ALN coating as a multifunctional protecting layer on the tooth surface for high-efficiency prevention and treatment of dental caries.
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