不利影响
免疫系统
免疫疗法
皮疹
癌症
医学
癌症治疗
免疫
免疫学
癌症免疫疗法
生物信息学
生物
药理学
内科学
作者
Yanek Jiménez-Andrade,Jessica L. Flesher,Jin Mo Park
标识
DOI:10.1016/j.hoc.2024.05.002
摘要
Pruritus, rash, and various other forms of dermatotoxicity are the most frequent adverse events among patients with cancer receiving targeted molecular therapy and immunotherapy. Immune checkpoint inhibitors, macrophage-targeting agents, and epidermal growth factor receptor/MEK inhibitors not only exert antitumor effects but also interfere with molecular pathways essential for skin immune homeostasis. Studying cancer therapy-induced dermatotoxicity helps us identify molecular mechanisms governing skin immunity and deepen our understanding of human biology. This review summarizes new mechanistic insights emerging from the analysis of cutaneous adverse events and discusses knowledge gaps that remain to be closed by future research.
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