Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression

内科学 内分泌学 卵泡期 卵泡闭锁 雄激素受体 生物 雄激素 排卵 卵泡 促卵泡激素 激素 促黄体激素 医学 前列腺癌 癌症
作者
Aritro Sen,Hen Prizant,Allison Light,Anindita Biswas,Emily Hayes,Hojoon Lee,David H. Barad,Norbert Gleicher,Stephen R. Hammes
出处
期刊:Proceedings of the National Academy of Sciences 卷期号:111 (8): 3008-3013 被引量:219
标识
DOI:10.1073/pnas.1318978111
摘要

Although androgen excess is considered detrimental to women's health and fertility, global and ovarian granulosa cell-specific androgen-receptor (AR) knockout mouse models have been used to show that androgen actions through ARs are actually necessary for normal ovarian function and female fertility. Here we describe two AR-mediated pathways in granulosa cells that regulate ovarian follicular development and therefore female fertility. First, we show that androgens attenuate follicular atresia through nuclear and extranuclear signaling pathways by enhancing expression of the microRNA (miR) miR-125b, which in turn suppresses proapoptotic protein expression. Second, we demonstrate that, independent of transcription, androgens enhance follicle-stimulating hormone (FSH) receptor expression, which then augments FSH-mediated follicle growth and development. Interestingly, we find that the scaffold molecule paxillin regulates both processes, making it a critical regulator of AR actions in the ovary. Finally, we report that low doses of exogenous androgens enhance gonadotropin-induced ovulation in mice, further demonstrating the critical role that androgens play in follicular development and fertility. These data may explain reported positive effects of androgens on ovulation rates in women with diminished ovarian reserve. Furthermore, this study demonstrates mechanisms that might contribute to the unregulated follicle growth seen in diseases of excess androgens such as polycystic ovary syndrome.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
停停走走发布了新的文献求助10
刚刚
学术大白完成签到,获得积分10
刚刚
田様应助蒋50采纳,获得30
1秒前
充电宝应助英勇的鱼采纳,获得10
2秒前
2秒前
6秒前
46464号发布了新的文献求助10
7秒前
科研通AI2S应助停停走走采纳,获得10
8秒前
10秒前
10秒前
白十八完成签到 ,获得积分10
11秒前
怕黑的立轩完成签到,获得积分20
13秒前
13秒前
落后夏瑶完成签到,获得积分10
14秒前
jerry完成签到,获得积分10
14秒前
txyouniverse完成签到 ,获得积分10
16秒前
在水一方应助Mok采纳,获得10
19秒前
20秒前
20秒前
Hello应助三千弱水为君饮采纳,获得10
20秒前
张东磊完成签到,获得积分20
20秒前
21秒前
Akim应助谁在说话采纳,获得10
24秒前
24秒前
24秒前
tangtang发布了新的文献求助10
24秒前
张东磊发布了新的文献求助10
25秒前
27秒前
27秒前
文献完成签到,获得积分10
28秒前
29秒前
Little青完成签到 ,获得积分10
31秒前
dadada发布了新的文献求助10
33秒前
Mok发布了新的文献求助10
33秒前
卓矢完成签到 ,获得积分10
34秒前
桐桐应助YESKY采纳,获得10
38秒前
米津浅兮应助dadada采纳,获得10
38秒前
RATHER完成签到,获得积分10
40秒前
NZH驳回了bkagyin应助
40秒前
无花果应助无私诗云采纳,获得10
40秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
A Dissection Guide & Atlas to the Rabbit 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3082501
求助须知:如何正确求助?哪些是违规求助? 2735703
关于积分的说明 7538567
捐赠科研通 2385300
什么是DOI,文献DOI怎么找? 1264761
科研通“疑难数据库(出版商)”最低求助积分说明 612786
版权声明 597665