止血
血管性血友病因子
血栓形成
小动脉
凝结
背景(考古学)
绉肌
内科学
内分泌学
医学
免疫学
生物
微循环
血小板
古生物学
作者
Julia Tilburg,Reheman Adili,Thankam Nair,Megan Hawley,David C. Tuk,Madeline Jackson,Henri M.H. Spronk,Henri H. Versteeg,Thomas E. Carey,Bart J.M. van Vlijmen,Chrissta X. Maracle,Michael Holinstat
标识
DOI:10.1016/j.thromres.2018.09.057
摘要
Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute Carrier Family 44 Member 2 protein (SLC44A2). Thus far, SLC44A2 has not been studied in the context of thrombosis, and may be a unique contributor to thrombotic disease. Here we utilize mice lacking SLC44A2 (Slc44a2-/-) to evaluate a possible role of SLC44A2 in hemostasis.Slc44a2-/- mice were evaluated in key aspects of normal hemostasis including a challenge of vascular damage by applying laser induced injury to the cremaster muscle arteriole.Slc44a2-/- mice had comparable levels of thrombin generation and gene expression of coagulation related genes, as compared to littermate wild type controls. Lower levels of circulating plasma Von Willebrand factor (VWF) were measured in Slc44a2-/- mice, while no difference in VWF multimerization or vascular localization was detected. Upon in vivo laser injury of the cremaster arterioles, we detected an impairment of clot formation for Slc44a2-/- mice.Although mice lacking SLC44A2 are normal for several hemostasis parameters, we do observe a reduction of plasma VWF levels and an altered response upon vascular damage, which suggests that SLC44A2 contributes to hemostasis upon injury. These findings are in line with the reported GWAS data and support further research on SLC44A2 in thrombosis.
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