疾病
病理
生物
阿尔茨海默病
人脑
内科学
医学
神经科学
作者
Xu Chen,Riccardo Calandrelli,John Girardini,Zhangming Yan,Zhiqun Tan,Xiangmin Xu,Annie Hiniker,Sheng Zhong
标识
DOI:10.1016/j.cmet.2022.02.008
摘要
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
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