化学
一氧化氮
免疫系统
傅里叶变换红外光谱
多酚
一氧化氮合酶
生物化学
抗氧化剂
生物
免疫学
化学工程
有机化学
工程类
作者
Fangmei Fu,Xiaoqin Pan,Riming Huang,Lianxiang Luo,Fanfan Huang,Wei Li,Haoran Zhang,Mingtao Zheng,Bingfu Lei
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2022-03-11
卷期号:5 (4): 1604-1609
被引量:11
标识
DOI:10.1021/acsabm.2c00016
摘要
The activation of immune cells by immunoregulatory active substances can improve the body immunity. Carbon dots (CDs) with immunoregulatory activity are rarely reported. In this study, transmission electron microscopy results demonstrate the existence of CDs in herbal tea, while Fourier transform infrared and X-ray photoelectron spectroscopy results suggest the participation of polyphenol in herbal tea CD (H-CD) formation. The photoluminescence spectrum has shown that H-CDs have fluorescence emission at 565 nm and exhibit an excitation-dependent property. The toxicity and immunostimulatory activity of H-CDs on mouse macrophage RAW264.7 suggested that H-CDs had no toxicity to RAW264.7 cells. Meanwhile, compared with herbal tea, H-CDs have more obvious effect of promoting the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In addition, the secretion of nitric oxide (NO) was promoted by H-CDs. This work suggests that H-CDs have stronger immunoregulatory function than that of original herbal tea, which provides a direction for the application of phenolic hydroxyl-modified CDs in the biomedical field.
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