Elevated creatine phosphokinase levels associated with linezolid therapy

药店 医学 医疗保健 图书馆学 家庭医学 政治学 计算机科学 法学
作者
Glenn W. Allison,Rocco J. Perla,Paul Belliveau,Sheryn M. Angelis
出处
期刊:American Journal of Health-system Pharmacy [Oxford University Press]
卷期号:66 (12): 1097-1100 被引量:11
标识
DOI:10.2146/ajhp080228
摘要

A case of elevated creatine phosphokinase (CPK) levels associated with linezolid therapy in a patient on chronic antihyperlipidemic therapy is presented.A 79-year-old Caucasian man with a primary diagnosis of acute hemoptysis secondary to pneumonia was admitted to the medical-surgical intensive care unit. A chest radiograph showed a large, right, lower-lobe infiltrate with alveolar consolidation. The patient's medical history included hyperlipidemia that was chronically treated with lovastatin and gemfibrozil. Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia was suspected and confirmed. Vancomycin 1 g i.v. every 12 hours was administered for approximately 10 days into the admission and switched to linezolid 600 mg i.v. every 12 hours after a lack of response to vancomycin. On hospital day 11, the patient's CPK concentration was 47 units/L. Seven days later, his CPK concentration was 2584 units/L and his lovastatin and gemfibrozil were discontinued on that day. The patient's CPK concentration peaked at 5369 units/L on the following day, and linezolid was discontinued at that point. One week later, his CPK concentration was 28 units/L. Approximately two weeks after the patient's CPK levels normalized, he developed numerous complications. The patient died as a result of respiratory failure 11 days after being extubated, which occurred about 38 days after his admission. Although concomitant use of statins and gemfibrozil is known to increase the risk for CPK elevations, the continued rise in CPK levels after discontinuation of antihyperlipidemic therapy and the rapid time course for normalization after linezolid discontinuation are more consistent with an event associated with linezolid initiation.A patient on chronic antihyperlipidemic therapy developed elevated CPK levels after receiving linezolid for the treatment of MRSA pneumonia.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
灵巧书文发布了新的文献求助10
2秒前
1821977451完成签到,获得积分10
3秒前
今后应助sukai采纳,获得10
3秒前
宋晓蓝完成签到,获得积分10
5秒前
5秒前
廉三问完成签到,获得积分10
5秒前
7秒前
邓力发布了新的文献求助10
8秒前
balabala完成签到,获得积分10
8秒前
田様应助乙二胺四乙酸采纳,获得10
9秒前
onepunch完成签到,获得积分10
9秒前
动人的黄豆完成签到,获得积分10
10秒前
11秒前
hh发布了新的文献求助10
14秒前
14秒前
15秒前
暴富发布了新的文献求助10
17秒前
18秒前
18秒前
善良的虔发布了新的文献求助10
18秒前
追寻的飞薇完成签到,获得积分10
20秒前
21秒前
MJX完成签到,获得积分10
21秒前
22秒前
25秒前
25秒前
凹凸先森应助吴彦鸿采纳,获得20
25秒前
小陈栗子发布了新的文献求助10
26秒前
邓力完成签到,获得积分10
29秒前
29秒前
安子完成签到,获得积分10
30秒前
30秒前
乐乐应助aqaqaqa采纳,获得10
31秒前
33秒前
积极的仙人柱应助michellewu采纳,获得10
33秒前
两酒窝完成签到,获得积分10
34秒前
35秒前
赖不弱发布了新的文献求助10
37秒前
小二郎应助tFtrx采纳,获得10
37秒前
善良的虔完成签到,获得积分10
38秒前
高分求助中
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 500
Spatial Political Economy: Uneven Development and the Production of Nature in Chile 400
Research on managing groups and teams 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3329635
求助须知:如何正确求助?哪些是违规求助? 2959215
关于积分的说明 8594779
捐赠科研通 2637692
什么是DOI,文献DOI怎么找? 1443715
科研通“疑难数据库(出版商)”最低求助积分说明 668827
邀请新用户注册赠送积分活动 656261