硝普钠
介孔二氧化硅
药物输送
角膜
眼压
开角型青光眼
青光眼
材料科学
一氧化氮
小梁网
纳米颗粒
渗透(战争)
药理学
医学
生物医学工程
介孔材料
眼科
化学
纳米技术
内科学
有机化学
催化作用
工程类
运筹学
作者
Chunchun Hu,Jianguo Sun,Yu Zhang,Jian Chen,Yuan Lei,Xinghuai Sun,Yonghui Deng
标识
DOI:10.1002/adhm.201801047
摘要
Abstract Nitric oxide (NO) donors are ideal drug candidates for reducing intraocular pressure in the treatment of glaucoma. However, poor cornea penetration, short duration of efficacy, and narrow therapeutic index of most NO donors obstruct their clinical applications in glaucoma treatment. This study reports a novel NO donor delivery system based on mesoporous silica nanoparticles that can readily overcome the above difficulties and deliver the NO‐donating drug sodium nitroprusside to the target tissues (trabecular meshwork and Schlemm's canal). Mesoporous silica nanoparticles loaded with sodium nitroprusside can produce more exogenous NO and sustain higher NO concentration in animal eye models, which significantly extend the duration of intraocular pressure reduction from 3 to 48 h with only 1/40 of the dose of sodium nitroprusside solution. These findings open up the possibility of mesoporous silica nanoparticles loading sodium nitroprusside for effective management of ocular hypertension.
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