肿瘤浸润淋巴细胞
免疫学
免疫疗法
癌症研究
生物
过继性细胞移植
离体
细胞毒性T细胞
T细胞
干细胞
CD8型
免疫系统
体内
体外
细胞生物学
生物技术
生物化学
作者
Sri Krishna,Frank J. Lowery,Amy R. Copeland,Erol Bahadiroglu,Ratnadeep Mukherjee,Li Jia,James Anibal,Abraham Sachs,Serifat Adebola,Devikala Gurusamy,Zhiya Yu,Victoria Hill,Jared J. Gartner,Yong F. Li,Maria R. Parkhurst,Biman C. Paria,Pia Kvistborg,Michael C. Kelly,Stephanie L. Goff,Grégoire Altan‐Bonnet,Paul F. Robbins,Steven A. Rosenberg
出处
期刊：Science
[American Association for the Advancement of Science (AAAS)]
日期：2020-12-10
卷期号：370 (6522): 1328-1334
被引量：366
标识
DOI：10.1126/science.abb9847
摘要
Adoptive T cell therapy (ACT) using ex vivo-expanded autologous tumor-infiltrating lymphocytes (TILs) can mediate complete regression of certain human cancers. The impact of TIL phenotypes on clinical success of TIL-ACT is currently unclear. Using high-dimensional analysis of human ACT products, we identified a memory-progenitor CD39-negative stem-like phenotype (CD39
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