Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation

(Neuron 109, 1963–1978.e1–e5; June 16, 2021) In our paper, Figure 4 used two methods (droplet formation and centrifugation) to show that only Rapsn full length or TPR1-7 is able to phase condensate, but not CC-RING, TPR1-2, TPR3-4, TPR5-7, or TPR1-4. As a result of an oversight in the making of the figure, the image of TPR5-7 in Figure 4H was mistakenly duplicated in CC-RING, TPR1-2, and TPR3-4. Figure 4H has now been corrected. The correction does not affect the conclusions of the droplet formation experiment. We sincerely apologize for the error.Figure 4HMultivalent binding of TPR domains for Rapsn LLPS (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formationXing et al.NeuronMay 24, 2021In BriefRapsn is critical for acetylcholine receptor (AChR) clustering and NMJ formation. Xing et al. show that Rapsn undergoes phase separation and that the resulting condensates recruit the AChR and signaling proteins to form membraneless compartments. These processes are compromised by congenital myasthenic syndrome mutations of Rapsn. Full-Text PDF Open Archive