化学
G-四倍体
烷基化
DNA
计算生物学
组合化学
生物化学
生物
催化作用
作者
Norihiro Sato,Shuntaro Takahashi,Hisae Tateishi‐Karimata,Madoka E. Hazemi,Tomoko Chikuni,Kazumitsu Onizuka,Naoki Sugimoto,Fumi Nagatsugi
摘要
The G-quadruplex structure has been found in biologically significant regions of the genomic DNA, including the telomere and promoter regions, and is known to play an important role in a number of biological processes. In this paper, we report the development of alkylating probes for the G-quadruplex structure and evaluation of the properties of the modified G-quadruplex structure.
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