HLA-B
人类白细胞抗原
生物
计算生物学
免疫学
微生物学
遗传学
抗原
作者
Eric Brown,Phuong Nguyen,Ramnik J. Xavier
出处
期刊:PubMed
日期:2024-08-06
标识
DOI:10.1016/j.chembiol.2024.07.012
摘要
The strong association of the human leukocyte antigen B∗27 alleles (HLA-B∗27) with spondyloarthritis and related rheumatic conditions has long fascinated researchers, yet the precise mechanisms underlying its pathogenicity remain elusive. Here, we review how interplay between the microbiome, the immune system, and the enigmatic HLA-B∗27 could trigger spondyloarthritis, with a focus on whether HLA-B∗27 presents an arthritogenic peptide. We propose mechanisms by which the unique biochemical characteristics of the HLA-B∗27 protein structure, particularly its peptide binding groove, could dictate its propensity to induce pathological T cell responses. We further provide new insights into how TRBV9
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