Refractory IgA pemphigus successfully managed with adalimumab as monotherapy

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 21, Issue 12 p. 1560-1562 CLINICAL LETTER Refractory IgA pemphigus successfully managed with adalimumab as monotherapy Juan José Lluch-Galcerá, Corresponding Author Juan José Lluch-Galcerá [email protected] orcid.org/0000-0003-0005-0318 Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain Correspondence Juan José Lluch Galcerá, Dermatology department, Hospital Universitari Germans Trias i Pujol, C/ Carretera de Canyet, s/n, 08916 Badalona, Barcelona, Spain. Email: [email protected]Search for more papers by this authorCarmen Alcoverro, Carmen Alcoverro Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorEugeni Prat, Eugeni Prat Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorManel Martinez-Molina, Manel Martinez-Molina Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa, Isabel Bielsa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorJulio Bassas, Julio Bassas Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this author Juan José Lluch-Galcerá, Corresponding Author Juan José Lluch-Galcerá [email protected] orcid.org/0000-0003-0005-0318 Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain Correspondence Juan José Lluch Galcerá, Dermatology department, Hospital Universitari Germans Trias i Pujol, C/ Carretera de Canyet, s/n, 08916 Badalona, Barcelona, Spain. Email: [email protected]Search for more papers by this authorCarmen Alcoverro, Carmen Alcoverro Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorEugeni Prat, Eugeni Prat Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorManel Martinez-Molina, Manel Martinez-Molina Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa, Isabel Bielsa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorJulio Bassas, Julio Bassas Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this author First published: 24 October 2023 https://doi.org/10.1111/ddg.15232Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Kridin K, Patel PM, Jones VA, et al. IgA pemphigus: A systematic review. J Am Acad Dermatol. 2020; 82(6): 1386-1392. 10.1016/j.jaad.2019.11.059 CASPubMedWeb of Science®Google Scholar 2Hendrix JD, Mangum KL, Zone JJ, et al. Cutaneous IgA deposits in bullous diseases function as ligands to mediate adherence of activated neutrophils. J Invest Dermatol. 1990; 94(5): 667-672. 10.1111/1523-1747.ep12876246 CASPubMedWeb of Science®Google Scholar 3Kridin K, Schmidt E. Epidemiology of Pemphigus. JID Innov. 2021; 1(1):100004. 10.1016/j.xjidi.2021.100004 PubMedGoogle Scholar 4Aslanova M, Yarrarapu SNS, Zito PM. IgA Pemphigus. [Updated 2023 Mar 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519063/#_NBK519063_pubdet_ [Last accessed April 1, 2023]. Google Scholar 5Porro AM, de Caetano LVN, de Maehara LSN, dos Enokihara MMS. Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus. An Bras Dermatol. 2014; 89(1): 96-106. 10.1590/abd1806-4841.20142459 PubMedWeb of Science®Google Scholar 6Hashimoto T, Teye K, Ishii N. Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University. Br J Dermatol. 2017; 176(1): 168-175. 10.1111/bjd.14780 CASPubMedWeb of Science®Google Scholar 7Howell SM, Bessinger GT, Altman CE, Belnap CM. Rapid response of IgA pemphigus of the subcorneal pustular dermatosis subtype to treatment with adalimumab and mycophenolate mofetil. J Am Acad Dermatol. 2005; 53(3): 541-543. 10.1016/j.jaad.2005.02.051 PubMedWeb of Science®Google Scholar 8Moreno ACL, Santi CG, Gabbi TVB, et al. IgA pemphigus: case series with emphasis on therapeutic response. J Am Acad Dermatol. 2014; 70(1): 200-201. 10.1016/j.jaad.2013.09.037 PubMedWeb of Science®Google Scholar 9Cross A, Moots RJ, Edwards SW. The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. Blood. 2008; 111(2): 878-884. 10.1182/blood-2007-05-087833 CASPubMedWeb of Science®Google Scholar 10Lokuta MA, Huttenlocher A. TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J Leukoc Biol. 2005; 78(1): 210-219. 10.1189/jlb.0205067 CASPubMedWeb of Science®Google Scholar Volume21, Issue12December 2023Pages 1560-1562 ReferencesRelatedInformation