肌萎缩侧索硬化
神经科学
医学
物理医学与康复
生物
病理
疾病
作者
Marlene Tahedl,Ee Ling Tan,Jana Kleinerová,Siobhan Delaney,Jennifer C. Hengeveld,Mark A. Doherty,Russell L. McLaughlin,Pierre‐François Pradat,Cédric Raoul,Fabrice Ango,Orla Hardiman,Kai Ming Chang,Jasmin Lope,Peter Bede
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2024-07-23
卷期号:103 (2)
标识
DOI:10.1212/wnl.0000000000209623
摘要
Amyotrophic lateral sclerosis (ALS) is predominantly associated with motor cortex, corticospinal tract (CST), brainstem, and spinal cord degeneration, and cerebellar involvement is much less well characterized. However, some of the cardinal clinical features of ALS, such as dysarthria, dysphagia, gait impairment, falls, and impaired dexterity, are believed to be exacerbated by coexisting cerebellar pathology. Cerebellar pathology may also contribute to cognitive, behavioral, and pseudobulbar manifestations. Our objective was to systematically assess both intracerebellar pathology and cerebrocerebellar connectivity alterations in a genetically stratified cohort of ALS.
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