材料科学
纳米颗粒
涂层
纳米技术
胶体金
日冕(行星地质学)
表面改性
化学工程
物理
天体生物学
维纳斯
工程类
作者
Narjes Dridi,Zhicheng Jin,Woody Perng,Hedi Mattoussi
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-03-12
卷期号:18 (12): 8649-8662
被引量:6
标识
DOI:10.1021/acsnano.3c08005
摘要
There has been much interest in integrating various inorganic nanoparticles (nanoscale colloids) in biology and medicine. However, buildup of a protein corona around the nanoparticles in biological media, driven by nonspecific interactions, remains a major hurdle for the translation of nanomedicine into clinical applications. In this study, we investigate the interactions between gold nanoparticles and serum proteins using a series of dihydrolipoic acid (DHLA)-based ligands. We employed gel electrophoresis combined with UV–vis absorption and dynamic light scattering to correlate protein adsorption with the nature and size of the ligand used. For instance, we found that AuNPs capped with DHLA alone promote nonspecific protein adsorption. In comparison, capping AuNPs with polyethylene glycol- or zwitterion-appended DHLA essentially prevents corona formation, regardless of ligand charge and size. Our results highlight the crucial role of surface chemistry and core material in protein corona formation and offer valuable information for the design of colloidal nanomaterials for biological applications.
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