化学
恶唑
环加成
催化作用
羧酸
药物化学
有机化学
组合化学
作者
Zhanjun Li,Yalin Zhang,Manman Sun,Ye Zhang,Zhaoxiang Lu,Yupeng Deng,Xianqiang Huang,Guodong Shen
标识
DOI:10.1021/acs.joc.3c02641
摘要
The La(OTf)3-catalyzed [3+2] cycloaddition reactions for the synthesis of benzo[d]oxazoles/benzofurans via quinones and 1,2-di-tert-butyl-3-(cyanimino)diaziridine (1,3-di-tert-butyl-2-cyanoguanidine)/vinyl azides have been explored. A series of 5-hydroxybenzofuran-4-carboxylic acid derivatives and 5-hydroxybenzo[d]oxazole-4-carboxylic acid derivatives were conveniently obtained with high yields and good stereoselectivities, which could be used for further transformations to valuable compounds.
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