T细胞受体
生物
基因重排
基因
突变体
分子生物学
克隆缺失
细胞生物学
突变
T细胞
遗传学
免疫系统
作者
Shigeyoshi Itohara,Peter Mombaerts,Juan J. Lafaille,John Iacomini,Andrew Nelson,Alan R. Clarke,Martin Hooper,Andrew G. Farr,Susumu Tonegawa
出处
期刊:Cell
[Elsevier]
日期:1993-02-01
卷期号:72 (3): 337-348
被引量:513
标识
DOI:10.1016/0092-8674(93)90112-4
摘要
T cells bearing T cell receptor (TCR) gamma and delta chain heterodimers are first generated early in ontogeny. They form distinct subsets that differ in their TCR repertoires and tissue distribution. Disruption of the mouse TCR C delta gene segment by a gene targeting method caused the complete loss of T cells bearing TCR gamma delta chains, but had little or no effect on the development of T cells bearing TCR alpha beta chains. The analyses of TCR gamma and delta genes in the mutant mice suggest that intracellular mechanisms acting at the level of DNA rearrangement play key roles in the differential gamma and delta gene rearrangements and in the generation of the highly restricted junctional sequences during fetal thymic development.
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