ESCRT公司
胞质分裂
细胞生物学
内体
萌芽
塞普汀
化学
膜泡运输蛋白质类
转运蛋白
膜
生物
细胞
细胞分裂
生物化学
液泡蛋白分选
细胞内
作者
Ana Joaquina Jiménez,Paolo Maiuri,Julie Lafaurie-Janvore,Séverine Divoux,Matthieu Piel,Franck Perez
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2014-02-28
卷期号:343 (6174)
被引量:556
标识
DOI:10.1126/science.1247136
摘要
ESCRT Your Wound Away The ESCRT (endosomal sorting complex required for transport) protein complex plays a role in budding into multivesicular bodies, in cytokinesis, and in HIV budding. Now, Jimenez et al. (p. 10.1126/science.1247136 , published online 30 January) propose a role for ESCRT proteins in wound repair at the plasma membrane. In vivo imaging, modeling, and electron microscopy were used to reveal how the ESCRTs participate in a rapid energy-independent, calcium-dependent, membrane-shedding process at the plasma membrane that reseals small wounds caused by toxins or laser treatment.
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