医学
优势比
母乳喂养
儿科
怀孕
病因学
混淆
逻辑回归
胎龄
置信区间
先天性畸形
产科
人口
病例对照研究
内科学
环境卫生
生物
遗传学
作者
Paula Rios,Helen D. Bailey,Laurent Orsi,Brigitte Lacour,Dominique Valteau‐Couanet,Dominique Lévy,Nadège Corradini,Guy Leverger,Anne Sophie Defachelles,Marion Gambart,Nicolas Sirvent,Estelle Thébaud,Stéphane Ducassou,Jacqueline Clavel
摘要
Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, is the most common malignancy among infants. The aetiology of NB is largely unknown. We conducted a pooled analysis to explore whether there is an association between NB and preconception and perinatal factors using data from two French national population‐based case‐control studies. The mothers of 357 NB cases and 1783 controls younger than 6 years, frequency‐matched by age and gender, responded to a telephone interview that focused on demographic, socioeconomic and perinatal characteristics, childhood environment, life‐style and maternal reproductive history. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. After controlling for matching variables, study of origin and potential confounders, being born either small (OR 1.4 95% CI 1.0‐2.0) or large (OR 1.5 95% CI 1.1–2.2) for gestational age and, among children younger than 18 months, having congenital malformations (OR 3.6 95% CI 1.3–8.9), were significantly associated with NB. Inverse associations were observed with breastfeeding (OR 0.7 95% CI 0.5–1.0) and maternal use of any supplements containing folic acid, vitamins or minerals (OR 0.5 95% CI 0.3–0.9) during the preconception period. Our findings reinforce the hypothesis that fetal growth anomalies and congenital malformations may be associated with an increased risk of NB. Further investigations are needed in order to clarify the role of folic acid supplementation and breastfeeding, given their potential importance in NB prevention.
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