化学
设计药物
质谱法
色谱法
麻醉药
光电二极管
哌嗪
麻醉性镇痛药
气相色谱-质谱法
高效液相色谱法
气相色谱法
药品
有机化学
药理学
物理
精神科
吗啡
医学
量子力学
心理学
作者
Misako Takahashi,Machiko Nagashima,Jin Suzuki,Takako Seto,Ichirou Yasuda,Takemi Yoshida
出处
期刊:Talanta
[Elsevier]
日期:2009-02-01
卷期号:77 (4): 1245-1272
被引量:43
标识
DOI:10.1016/j.talanta.2008.07.062
摘要
In order to quickly confirm a potentially hazardous psychoactive designer drug (a compound in which part of the molecular structure of a stimulant or narcotic has been modified), we created a psychoactive drugs data library by performing analysis using liquid chromatography with photodiode array spectrophotometry (LC/PDA) and gas chromatography–mass spectrometry (GC/MS). The data in this library consist of the LC capacity factor (k′) ratios in relation to the internal standard, the ultraviolet (UV) spectra and the MS spectra of 104 compounds. By performing a comparative study of the data in this report with the analytical data for commercial and illegal drug products, it is possible to quickly identify the psychoactive designer drugs in 205 purchased products by using the library. Further, it is possible to analogize the structure of drugs for which there is no matching data in the library using similar data. Furthermore, when structural isomers of controlled substances have detected from the presented library, similarity of their biological effects on human will be predicted, thus leading to regulate their public circulation. Examples of these types of isomers include, for instance, the narcotic 3,4,5-trimethoxyamphetamine (TMA) and its positional isomers 2,4,5-trimethoxyamphetamine (TMA-2) and 2,4,6-trimethoxyamphetamine (TMA-6), or the narcotic 1-(3-chlorophenyl)piperazine (3CPP) and its isomers 1-(o-chlorophenyl)piperazine (2CPP) and 1-(p-chlorophenyl)piperazine (4CPP). Differentiation of these compounds is necessary in regulating them, and we report here the results of a study of a method to confirm these compounds using the present library.
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