雅罗维亚
代谢工程
底盘
萜类
合成生物学
生产(经济)
化学
生化工程
计算生物学
生物技术
生物化学
生物
酵母
基因
工程类
经济
宏观经济学
结构工程
作者
Jingnan Wang,Zhangying Lei,Wanyun Ma,Wenqi Ma,Yujia Jiang,Wankui Jiang,Yidong Wan,Fengxue Xin,Wenming Zhang,Min Jiang
标识
DOI:10.1021/acs.iecr.4c02475
摘要
Yarrowia lipolytica is an unconventional oleaginous yeast with special physiological characteristics. Due to its high flux of acetyl-CoA, extensive substrate spectra, clear gene sequences, and mature genetic modification tools, it has received widespread attention as a chassis strain for the production of various compounds. In this Perspective, we summarize the biosynthetic pathway of terpenoids. The advantages and application prospects of using Y. lipolytica as chassis to produce natural products are introduced. Strategies to further improve the metabolite production efficiency are also discussed, which will provide references and guidance for further expanding application of Y. lipolytica. At present, Y. lipolytica is used to produce a variety of biochemicals. With the development of synthetic biology, the transformation tools of Y. lipolytica can be developed in the future to improve expression capability. It can not only simplify the operation process, but also promote the production yield.
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