荧光
体内
化学
生物物理学
临床前影像学
荧光寿命成像显微镜
淀粉样蛋白(真菌学)
近红外光谱
神经科学
生物
量子力学
物理
生物技术
无机化学
作者
Jia Miao,Minqian Miao,Yue Jiang,Min Zhao,Qing Li,Yuan Zhang,Yi An,Kanyi Pu,Qingqing Miao
标识
DOI:10.1002/anie.202216351
摘要
Abstract Fluorescence imaging in the second near‐infrared (NIR‐II) window holds great promise for in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and deep understanding of Alzheimer's disease (AD); however, it has been rarely exploited. Herein, we report the development of NIR‐II fluorescent reporters with a donor‐π‐acceptor (D‐π‐A) architecture for specific detection of Aβ plaques in AD‐model mice. Among all the designed probes, DMP2 exhibits the highest affinity to Aβ fibrils and can specifically activate its NIR‐II fluorescence after binding to Aβ fibrils via suppressed twisted intramolecular charge transfer (TICT) effect. With suitable lipophilicity for ideal blood–brain barrier (BBB) penetrability and deep‐tissue penetration of NIR‐II fluorescence, DMP2 possesses specific detection of Aβ plaques in in vivo AD‐model mice. Thus, this study presents a potential agent for non‐invasive imaging of Aβ plaques and deep deciphering of AD progression.
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