类阿片
阿片肽
药理学
医学
更安全的
肽
化学
受体
内科学
生物化学
计算机科学
计算机安全
作者
Abbe Eliasof,Lee‐Yuan Liu‐Chen,Yangmei Li
标识
DOI:10.1016/j.drudis.2024.103950
摘要
Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the treatment of pain, but activation of MOR with current opioid analgesics also produces harmful side effects, notably physical dependence, addiction, and respiratory depression. Opioid peptides have been accepted as promising candidates for the development of safer and more efficacious analgesics. To develop peptide-based opioid analgesics, strategies such as modification of endogenous opioid peptides, development of multifunctional opioid peptides, G protein-biased opioid peptides, and peripherally restricted opioid peptides have been reported. This review seeks to provide an overview of the opioid peptides that produce potent antinociception with much reduced side effects in animal models and highlight the potential advantages of peptides as safer opioid analgesics.
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