Diastereoselective palladium-catalyzed C(sp3)–H cyanomethylation of amino acid and carboxylic acid derivatives

Herein, we have developed an effective β-C(sp 3 )–H cyanomethylation reaction to prepare a wide range of important γ-cyano-α-amino acid and carboxylic acid derivatives by using commercially available inexpensive chloroacetonitrile.