环糊精
化学
三羧酸
高效液相色谱法
对映体
手性拆分
手性柱色谱法
有机化学
柠檬酸
手性固定相
色谱法
柠檬酸循环
酶
作者
Hui Li,Xiaoping Wang,Chengxiang Shi,Liang Zhao,Zuguang Li,Hongdeng Qiu
标识
DOI:10.1016/j.cclet.2022.06.029
摘要
In this work, a series of chiral phenethylamine synergistic tricarboxylic acid modified β-cyclodextrin bonded stationary phase for high performance liquid chromatography (HPLC) were synthesized via a simple one-pot synthesis approach. Various racemates (aryl alcohols, flavanones, triazoles, benzoin, etc.) were well separated on the tricarboxylic acid modified chiral stationary phases in both normal and reversed modes with good reproducibility and stability, and the influence of mobile phase composition on resolution (Rs) were deeply investigated. The RSD values of Rs for repeatability and column-to-column were below 1.28% and 3.05%, respectively. Hence, the fabrication of tricarboxylic acid modified chiral stationary phase (CSPs) is a new efficient strategy to improve the application of β-cyclodextrin as CSPs in the field of chromatography.
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