免疫学
免疫系统
实验性自身免疫性脑脊髓炎
细胞因子
淋巴因子
T辅助细胞
髓鞘碱性蛋白
T细胞
自身免疫性疾病
脑脊髓炎
生物
医学
抗体
髓鞘
多发性硬化
中枢神经系统
内分泌学
作者
Michael K. Racke,Adriana Bonomo,Dorothy E. Scott,Barbara Cannella,Alan D. Levine,Cedric S. Raine,Ethan M. Shevach,Martin Röcken
标识
DOI:10.1084/jem.180.5.1961
摘要
The properties and outcome of an immune response are best predicted by the lymphokine phenotype of the responding T cells. Cytokines produced by CD4+ T helper type 1 (Th1) T cells mediate delayed type hypersensitivity (DTH) and inflammatory responses, whereas cytokines produced by Th2 T cells mediate helper T cell functions for antibody production. To determine whether induction of Th2-like cells would modulate an inflammatory response, interleukin 4 (IL-4) was administered to animals with experimental allergic encephalomyelitis (EAE), a prototypic autoimmune disease produced by Th1-like T cells specific for myelin basic protein (MBP). IL-4 treatment resulted in amelioration of clinical disease, the induction of MBP-specific Th2 cells, diminished demyelination, and inhibition of the synthesis of inflammatory cytokines in the central nervous system (CNS). Modulation of an immune response from one dominated by excessive activity of Th1-like T cells to one dominated by the protective cytokines produced by Th2-like T cells may have applicability to the therapy of certain human autoimmune diseases.
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