催产素
血管催产素
内科学
内分泌学
食物摄入量
食欲
下丘脑
神经肽
敌手
神经肽Y受体
神经递质
摄食行为
食物消费
口渴
生物
化学
医学
中枢神经系统
受体
农业经济学
经济
作者
Rossana Arletti,Augusta Benelli,Alfio Bertolini
出处
期刊:Peptides
[Elsevier]
日期:1989-01-01
卷期号:10 (1): 89-93
被引量:311
标识
DOI:10.1016/0196-9781(89)90082-x
摘要
Oxytocin, whether administered intraperitoneally (IP) (375–6,000 μg/kg) or intracerebroventricularly (ICV) (1–10 μg/rat), dose-dependently reduced food consumption and time spent eating and increased the latency to the first meal in rats fasted for 21 hr. Pretreatment with the oxytocin antagonist d(CH2)5Tyr(Me)-[Orn8]vasotocin (ICV 10 μg/rat) completely prevented the feeding inhibitory effect of an equal dose of ICV oxytocin, and per se increased food intake. Our data further support the hypothesis that oxytocin plays the role of neurotransmitter or neuromodulator in the CNS, and suggest that its involvement in a number of homeostatic systems may include appetite control.
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