组织蛋白酶
蛋白酵素
癌细胞
癌症
溶酶体
细胞生物学
转移
胞浆
程序性细胞死亡
生物
自噬
癌症研究
细胞凋亡
酶
生物化学
遗传学
作者
Nicole Fehrenbacher,Marja Jäättelä
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2005-04-15
卷期号:65 (8): 2993-2995
被引量:302
标识
DOI:10.1158/0008-5472.can-05-0476
摘要
Tumor invasion and metastasis are associated with altered lysosomal trafficking and increased expression of the lysosomal proteases termed cathepsins. Emerging experimental evidence suggests that such alterations in lysosomes may form an "Achilles heel" for cancer cells by sensitizing them to death pathways involving lysosomal membrane permeabilization and the release of cathepsins into the cytosol. Here, we highlight recent results on cancer-related changes in the composition and function of lysosomes, focusing on possible implications for the development of novel cancer therapeutics that target tumor cell lysosomes.
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