微生物群
免疫学
炎症
Toll样受体
免疫系统
受体
TLR4型
抗体
生物
微生物学
先天免疫系统
生物化学
生物信息学
作者
Tomasz P. Wypych,Céline Pattaroni,Olaf Perdijk,Carmen Yap,Aurélien Trompette,Dovile Anderson,Darren J. Creek,Nicola Harris,Benjamin J. Marsland
标识
DOI:10.1038/s41590-020-00856-3
摘要
The constituents of the gut microbiome are determined by the local habitat, which itself is shaped by immunological pressures, such as mucosal IgA. Using a mouse model of restricted antibody repertoire, we identified a role for antibody-microbe interactions in shaping a community of bacteria with an enhanced capacity to metabolize L-tyrosine. This model led to increased concentrations of p-cresol sulfate (PCS), which protected the host against allergic airway inflammation. PCS selectively reduced CCL20 production by airway epithelial cells due to an uncoupling of epidermal growth factor receptor (EGFR) and Toll-like receptor 4 (TLR4) signaling. Together, these data reveal a gut microbe-derived metabolite pathway that acts distally on the airway epithelium to reduce allergic airway responses, such as those underpinning asthma.
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