肾脏疾病
医学
急性肾损伤
重症监护医学
肾切除术
病理生理学
内科学
生物信息学
肾
生物
作者
Ying Fu,Chengyuan Tang,Juan Cai,Guochun Chen,Dongshan Zhang,Zheng Dong
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2018-06-27
卷期号:315 (4): F1098-F1106
被引量:189
标识
DOI:10.1152/ajprenal.00199.2018
摘要
Acute kidney injury (AKI) is a contributing factor in the development and progression of chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI-CKD transition remains largely unclear. Animal models recapitulating this process are crucial to the research of the pathophysiology of AKI-CKD transition and the development of effective therapeutics. In this review, we present the commonly used rodent models of AKI-CKD transition, including bilateral ischemia-reperfusion injury (IRI), unilateral IRI, unilateral IRI with contralateral nephrectomy, multiple episodes of IRI, and repeated treatment of low-dose cisplatin, diphtheria toxin, aristolochic acid, or folic acid. The main merits and pitfalls of these models are also discussed. This review provides helpful information for establishing reliable and clinically relevant models for studying post-AKI development of chronic renal pathologies and the progression to CKD.
科研通智能强力驱动
Strongly Powered by AbleSci AI