Mercury(编程语言)
荧光
斯托克斯位移
赫拉
化学
选择性
生物物理学
荧光寿命成像显微镜
活体细胞成像
生物累积
纳米技术
材料科学
细胞
环境化学
计算机科学
生物化学
光学
生物
物理
催化作用
程序设计语言
作者
Wei-Long Cui,Zhihao Zhang,Lin Wang,Jianbo Qu,Jianyong Wang
标识
DOI:10.1016/j.saa.2021.120516
摘要
Giving the fact that mercury ions (Hg2+) is highly toxic, migratory and bioaccumulative and even very small amounts of mercury can cause serious damage to health, resulting in many diseases, such as abdominal pain, renal failure, nervous system damage. The content of mercury in drinking water quality standard of our country has been strictly limited. Therefore, it is of good research interest to develop a stable fluorescent probe capable of detecting the presence of mercury in biological cells. In this study, a novel fluorescent probe based on isophoronitriles scaffold, DNC-Hg, was designed and synthesized for monitoring mercury ion in living HeLa cells. The good properties of the probe may be attributed to the unique strong electron-absorbing group in the structural design, the good conjugation effect, and the mature Hg2+ recognition site. The probe exhibited good selectivity and stability, large Stokes shift(174 nm) and low cytotoxicity. Furthermore, this stable probe DNC-Hg could be used for cellular imaging.
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