上皮-间质转换
乳腺癌转移
转移
乳腺癌
远处转移
癌症转移
癌症研究
过渡(遗传学)
癌症
间充质干细胞
医学
肿瘤科
生物
内科学
病理
基因
遗传学
作者
Yang Liu,Yi Jiang,Peng Qiu,Tie Ma,Yang Bai,Jiawen Bu,Yueting Hu,Ming Jin,Tong Zhu,Xi Gu
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2024-08-15
卷期号:13
摘要
Distant metastasis is the major cause of death in patients with breast cancer. Epithelial–mesenchymal transition (EMT) contributes to breast cancer metastasis. Regulator of G protein-signaling (RGS) proteins modulates metastasis in various cancers. This study identified a novel role for RGS10 in EMT and metastasis in breast cancer. RGS10 protein levels were significantly lower in breast cancer tissues compared to normal breast tissues, and deficiency in RGS10 protein predicted a worse prognosis in patients with breast cancer. RGS10 protein levels were lower in the highly aggressive cell line MDA-MB-231 than in the poorly aggressive, less invasive cell lines MCF7 and SKBR3. Silencing RGS10 in SKBR3 cells enhanced EMT and caused SKBR3 cell migration and invasion. The ability of RGS10 to suppress EMT and metastasis in breast cancer was dependent on lipocalin-2 and MIR539-5p . These findings identify RGS10 as a tumor suppressor, prognostic biomarker, and potential therapeutic target for breast cancer.
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