硫氧还蛋白还原酶
化学
体外
取代基
硫氧还蛋白
立体化学
组合化学
细胞毒性T细胞
效力
酶
细胞凋亡
结构-活动关系
细胞培养
生物化学
生物
遗传学
作者
Anna Ņikitjuka,Melita Videja,Kristaps Krims‐Davis,Raivis Žalubovskis
标识
DOI:10.1002/cmdc.202300504
摘要
Abstract We aimed to design and synthesize 3‐methylenechroman‐2‐one derivatives and test their potency as TrxR1 inhibitors. A convenient and easy‐to‐handle synthetic approach to 3‐methylenechroman‐2‐ones was developed. The in vitro inhibitory activity towards recombinant TrxR1 was determined for the obtained compounds. The most potent representatives exhibited submicromolar TrxR1 inhibition activity (IC 50 varied from 0.29 μM to 10.2 μM). Structure‐activity relationship analysis indicates the beneficial role of the substituent at the position C‐6 of the core of chroman‐2‐one, where the derivatives containing halogen are the most active among the scope of compounds obtained. The most potent TrxR1 inhibitor of the series was further examined in in vitro cell‐based assays to assess cytotoxic effects on various cancer cell lines, and to evaluate their influence on cell apoptosis.
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