Further Preclinical Development of a Bio‐therapeutic Against Porphyromonas gingivalis for the control of Systemic and Neuro‐inflammation related Dementia and Alzheimer’s Disease

牙龈卟啉单胞菌 医学 痴呆 认知功能衰退 全身炎症 疾病 炎症 免疫学 神经炎症 血管性痴呆 牙周炎 内科学
作者
Peter L. Nara
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:19 (S12)
标识
DOI:10.1002/alz.079329
摘要

Abstract Addressing novel mechanisms and effective therapeutic treatments for cognitive decline, Dementia and Alzheimer’s Disease is a major public health need. Keystone Bio have identified that specific virulent strains of Porphyromonas gingivalis (Pg) and the release of specific virulence factors/toxins in the oral cavity as the primary driver/causation of systemic/neuro‐vascular inflammation/degenerative diseases i.e., cognitive decline/dementias/Alzheimer’s disease (Nara et. al 2021). A recent landmark finding was reported in a sub‐cohort analysis from a Phase 2/3 GAIN trial (n = 238) demonstrated that lowering the load of Pg in the mouth leads to a significant improvement of cognitive slowing at both 24 and 48 weeks in participants with mild to moderate AD. Another study showed lowering the load of Pg in the mouth had a favorable effect on AD‐related brain atrophy ( https://doi.org/10.1002/alz.12378 ). Pg OMVs and systemic system diseases has many well‐defined examples such as: cardiometabolic diseases‐ Pg OMVs attenuate insulin induced Akt/GSK‐3_ signaling in hepatic HepG2 cells, thereby causing changes in glucose metabolism in the liver and promoting the development of diabetes and increase vascular permeability by cleaving endothelial cell connexins such as PECAM‐1, thereby promoting cardiovascular diseases. Keystone Bio has further developed both a companion diagnostic (CDx) and a clinical, proof‐of‐concept tested, first generation, safe, efficacious, precision, bio‐therapeutic murine monoclonal antibody (KB‐001) for the diagnosis, treatment and monitoring against the oral bacteria and major virulent factor/toxin of Pg. The antibody engagement is with the later stages of the complex virulent factor/toxin secretion containing outer membrane vesicles from the bacteria thereby interfering/stopping all necessary metabolic, host defense, energy‐producing sources, adherence and biofilm formation and integrity (Nara et. al 2021). The talk will review what now seems like a solid case for causation in the role of virulent/toxin secreting strains of in neuro‐inflammation leading to cognitive decline, dementia, Sporadic Alzheimer’s disease and possibly Parkinson’s.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
悠悠完成签到,获得积分10
1秒前
1秒前
卓疾发布了新的文献求助10
2秒前
Tu发布了新的文献求助10
2秒前
dada完成签到,获得积分10
2秒前
xyy001完成签到,获得积分10
3秒前
3秒前
充电宝应助pinging采纳,获得10
4秒前
Alex发布了新的文献求助10
4秒前
传奇3应助悠悠采纳,获得10
4秒前
大个应助背后的果汁采纳,获得10
5秒前
阿刚发布了新的文献求助20
5秒前
6秒前
6秒前
李爱国应助墨阳初晴采纳,获得10
7秒前
拾云完成签到,获得积分10
8秒前
HZSY_WL发布了新的文献求助10
8秒前
Tu完成签到,获得积分20
8秒前
8秒前
FashionBoy应助无私诗云采纳,获得10
8秒前
9秒前
M张发布了新的文献求助10
9秒前
9秒前
糟糕的访梦完成签到,获得积分10
10秒前
12秒前
13秒前
InTroLLe发布了新的文献求助10
13秒前
14秒前
14秒前
酷波er应助宝川采纳,获得10
15秒前
爆米花应助救赎采纳,获得10
15秒前
cindy应助笑点低的怀莲采纳,获得10
16秒前
16秒前
伍寒烟发布了新的文献求助10
17秒前
浑续发布了新的文献求助30
17秒前
Liiiily完成签到,获得积分10
18秒前
烟花应助duan采纳,获得10
19秒前
墨阳初晴发布了新的文献求助10
19秒前
钙离子完成签到,获得积分10
20秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3083756
求助须知:如何正确求助?哪些是违规求助? 2737102
关于积分的说明 7543295
捐赠科研通 2386458
什么是DOI,文献DOI怎么找? 1265484
科研通“疑难数据库(出版商)”最低求助积分说明 613100
版权声明 597951