藤黄酸
生物相容性
化学
药品
体内
肝细胞癌
纳米颗粒
溶解度
药物输送
药代动力学
纳米技术
生物利用度
药理学
体外
癌症研究
生物化学
材料科学
有机化学
医学
生物技术
生物
作者
Ruijie Liu,He Li,Maoyu Liu,Lu Chen,Jun Hou,Jianyou Shi,Lan Bai
标识
DOI:10.1016/j.cclet.2022.05.089
摘要
Gambogic acid (GA) is a potential clinical anticancer drug that can exert antitumor effects via various molecular mechanisms. Notwithstanding, GA's low water solubility, poor stability, short half-life, and unavoidable toxic side effects have significantly hampered its clinical application. Erythrocyte membrane-coated nanoparticles (RBCM-NPs) improve drug's physicochemical properties, biocompatibility, and pharmacokinetic behaviors, allowing for long-term drug circulation and passive targeting. In this study, a novel biomimetic drug delivery system (DDS) against hepatocellular carcinoma was prepared by covering RBCM on GPP-NPs (GA-loaded mPEG-PLA NPs) to develop the [email protected] In comparison to RBCM-free nanoparticles and free GA, [email protected] improved the drug's water solubility, stability, safety, and anti-tumor activity in vivo. We expect that this bionic nanoparticle composite can expand the clinical applicability of GA and provide a feasible solution for the research and development of GA's nano-formulation.
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